The STS-V is the performance edition of the STS and shows that a domestic sedan can run alongside the world's best.

The STS-V comes with a supercharged V8 and a six-speed automatic; it is only available in rear-wheel drive. It has a higher level of standard equipment, including EZ Key with remote start, XM Satellite Radio, rear AV jacks, and rear obstacle detection, hand-wrapped leather surfaces with suede seat inserts, Olive Ash Burl wood and aluminum interior accents, rear climate system controls, and V-Series badging. Special paint and a sunroof are the only options.

The Cadillac STS-V is a carryover from 2006.